Discovery at the Organ

Directly control stimuli and observe responses

Build confidence preclinically

Spend less compared to transplant and in vivo studies

Make the most of experimental surgery resources

Progress in Organ and Cell Transplantation

Repair derangements of ischemia

Evaluate new preservation strategies

Transfect genes to express specific proteins

Deplete or inactivate passenger leukocytes

Bind to adhesion and co-stimulation sites

Deliver antiinflammatory, antithrombotic, and antiapoptosis drugs

Assess biomarker prognostics of transplant function

Enable blockade of surface protein pathways

Inhibit endothelial activation and the complement cascade

Relax arteries and reduce edema

Restore cellular energy levels

Deliver RNA interference to block expression of pro-inflammatory proteins

Precondition the pancreas to increase islet yields

Beyond Transplantation

Organ physiology

Enhanced imaging of perfusion, metabolism, cancers

Cellular transplantation

Organ-blood interaction

Genetically modified (knock-in and knock-out) organs

Acute organ failure

Drug absorption, distribution, metabolism, excretion, and toxicity